Publications

2024

• Bok S, Sun J, Greenblatt MB. Are Osteoblasts Multiple Cell Types? A New Diversity in Skeletal Stem Cells and Their Derivatives. J Bone Miner Res. Published online July 25, 2024. doi:10.1093/jbmr/zjae109

• Morse, Kyle W. MD; Sun, Jun PhD; Hu, Lingling PhD; Bok, Seoyeon PhD; Debnath, Shawon PhD; Cung, Michelle BA; Yallowitz, Alisha R. PhD; Meyers, Kathleen N. MS; Iyer, Sravisht MD; Greenblatt, Matthew B. MD, PhD. Development of Murine Anterior Interbody and Posterolateral Spinal Fusion Techniques. The Journal of Bone and Joint Surgery 106(8):p 735-745, April 17, 2024. DOI: 10.2106/JBJS.23.00690

• Sosa BR, Cung M, Suhardi VJ, et al. Capacity for large language model chatbots to aid in orthopedic management, research, and patient queries. J Orthop Res. 2024; 1-7. doi:10.1002/jor.25782

• Michelle Cung, Branden Sosa, He S Yang, Michelle M McDonald, Brya G Matthews, Annegreet G Vlug, Erik A Imel, Marc N Wein, Emily Margaret Stein, Matthew B Greenblatt, The performance of AI Chatbot Large Language Models to Address Skeletal Biology and Bone Health Queries, Journal of Bone and Mineral Research, 2024;, zjad007, https://doi.org/10.1093/jbmr/zjad007

2023

• Bok S, Yallowitz AR, Sun J, McCormick J, Cung M, Hu L, Lalani S, Li Z, Sosa BR, Baumgartner T, Byrne P, Zhang T, Morse KW, Mohamed FF, Ge C, Franceschi RT, Cowling RT, Greenberg BH, Pisapia DJ, Imahiyerobo TA, Lakhani S, Ross ME, Hoffman CE, Debnath S, Greenblatt MB. A multi-stem cell basis for craniosynostosis and calvarial mineralization. Nature. 2023 Sep;621(7980):804-812. doi: 10.1038/s41586-023-06526-2. Epub 2023 Sep 20. PMID: 37730988.

• Sun J, Hu L, Bok S, Yallowitz AR, Cung M, McCormick J, Zheng LJ, Debnath S, Niu Y, Tan AY, Lalani S, Morse KW, Shinn D, Pajak A, Hammad M, Suhardi VJ, Li Z, Li N, Wang L, Zou W, Mittal V, Bostrom MPG, Xu R, Iyer S, Greenblatt MB. A vertebral skeletal stem cell lineage driving metastasis. Nature. 2023 Sep;621(7979):602-609. doi: 10.1038/s41586-023-06519-1. Epub 2023 Sep 13. PMID: 37704733.

• Yallowitz AR, Shim JH, Xu R, Greenblatt MB. An angiogenic approach to osteoanabolic therapy targeting the SHN3-SLIT3 pathway. Bone. 2023 Jul;172:116761. doi: 10.1016/j.bone.2023.116761. Epub 2023 Apr 6. PMID: 37030497; PMCID: PMC10198948.

• Camilleri AE, Cung M, Hart FM, Pagovich OE, Crystal RG, Greenblatt MB, Stiles KM. Gene Therapy to Treat Osteopenia Associated With Chronic Ethanol Consumption and Aldehyde Dehydrogenase 2 Deficiency. JBMR Plus. 2023 Feb 16;7(4):e10723. doi: 10.1002/jbm4.10723. PMID: 37065630; PMCID: PMC10097638.

2022

• Bok S, Greenblatt MB. Shaping the sinuses: a novel Krt14+Ctsk+ cell lineage driving regenerative bone formation. Cell Res. 2022 Sep;32(9):791-792. doi: 10.1038/s41422-022-00694-y. PMID: 35836006; PMCID: PMC9437050.

• Sun J, Greenblatt MB. To the bones: mapping the skeletal LEPR+ pool to component cell types. EMBO J. 2022 Feb 15;41(4):e110343. doi: 10.15252/embj.2021110343. Epub 2022 Jan 10. PMID: 35005783; PMCID: PMC8844985.

2021

• Greenblatt MB, Debnath S. A stem-cell basis for skeletal ageing. Nature. 2021 Sep;597(7875):182-183. doi: 10.1038/d41586-021-02118-0. PMID: 34381222.

• Sun J, Shin DY, Eiseman M, Yallowitz AR, Li N, Lalani S, Li Z, Cung M, Bok S, Debnath S, Marquez SJ, White TE, Khan AG, Lorenz IC, Shim JH, Lee FS, Xu R, Greenblatt MB. SLITRK5 is a negative regulator of hedgehog signaling in osteoblasts. Nat Commun. 2021 Jul 29;12(1):4611. doi: 10.1038/s41467-021-24819-w. PMID: 34326333; PMCID: PMC8322311.

• Debnath S, Greenblatt MB. Specimen Preparation for Single-Cell Sequencing Analysis of Skeletal Cells. Methods Mol Biol. 2021;2221:89-100. doi: 10.1007/978-1-0716-0989-7_7. PMID: 32979200.

2020

• Bok S, Shin DY, Yallowitz AR, Eiseman M, Cung M, Xu R, Li N, Sun J, Williams AL, Scott JE, Su B, Shim JH, Greenblatt MB. MEKK2 mediates aberrant ERK activation in neurofibromatosis type I. Nat Commun. 2020 Nov 11;11(1):5704. doi: 10.1038/s41467-020-19555-6. PMID: 33177525; PMCID: PMC7658220.

• Sun J, Feng H, Xing W, Han Y, Suo J, Yallowitz AR, Qian N, Shi Y, Greenblatt MB, Zou W. Histone demethylase LSD1 is critical for endochondral ossification during bone fracture healing. Sci Adv. 2020 Nov 4;6(45):eaaz1410. doi: 10.1126/sciadv.aaz1410. PMID: 33148658; PMCID: PMC7673679.

• Li Z, Oh H, Cung M, Marquez SJ, Sun J, Hammad H, Janssens S, Pouliot P, Lambrecht BN, Yang YS, Shim JH, Greenblatt MB. TAOK3 is a MAP3K contributing to osteoblast differentiation and skeletal mineralization. Biochem Biophys Res Commun. 2020 Oct 22;531(4):497-502. doi: 10.1016/j.bbrc.2020.07.060. Epub 2020 Aug 14. PMID: 32807497; PMCID: PMC7494564.

• Kim JM, Yang YS, Park KH, Ge X, Xu R, Li N, Song M, Chun H, Bok S, Charles JF, Filhol-Cochet O, Boldyreff B, Dinter T, Yu PB, Kon N, Gu W, Takarada T, Greenblatt MB, Shim JH. A RUNX2 stabilization pathway mediates physiologic and pathologic bone formation. Nat Commun. 2020 May 8;11(1):2289. doi: 10.1038/s41467-020-16038-6. PMID: 32385263; PMCID: PMC7210266.

• Li N, Inoue K, Sun J, Niu Y, Lalani S, Yallowitz A, Yang X, Zhang C, Shen R, Zhao B, Xu R, Greenblatt MB. Osteoclasts are not a source of SLIT3. Bone Res. 2020 Feb 19;8:11. doi: 10.1038/s41413-020-0086-3. PMID: 32133214; PMCID: PMC7031526.

2019

• Greenblatt MB, Ono N, Ayturk UM, Debnath S, Lalani S. The Unmixing Problem: A Guide to Applying Single-Cell RNA Sequencing to Bone. J Bone Miner Res. 2019 Jul;34(7):1207-1219. doi: 10.1002/jbmr.3802. PMID: 31336008; PMCID: PMC6658136.

2018

• Debnath S, Yallowitz AR, McCormick J, Lalani S, Zhang T, Xu R, Li N, Liu Y, Yang YS, Eiseman M, Shim JH, Hameed M, Healey JH, Bostrom MP, Landau DA, Greenblatt MB. Discovery of a periosteal stem cell mediating intramembranous bone formation. Nature. 2018 Oct;562(7725):133-139. doi: 10.1038/s41586-018-0554-8. Epub 2018 Sep 24. PMID: 30250253; PMCID: PMC6193396.

• Xu R, Yallowitz A, Qin A, Wu Z, Shin DY, Kim JM, Debnath S, Ji G, Bostrom MP, Yang X, Zhang C, Dong H, Kermani P, Lalani S, Li N, Liu Y, Poulos MG, Wach A, Zhang Y, Inoue K, Di Lorenzo A, Zhao B, Butler JM, Shim JH, Glimcher LH, Greenblatt MB. Targeting skeletal endothelium to ameliorate bone loss. Nat Med. 2018 Jun;24(6):823-833. doi: 10.1038/s41591-018-0020-z. Epub 2018 May 21. PMID: 29785024; PMCID: PMC5992080.

2017

• Xu R, Zhang C, Shin DY, Kim JM, Lalani S, Li N, Yang YS, Liu Y, Eiseman M, Davis RJ, Shim JH, Greenblatt MB. c-Jun N-Terminal Kinases (JNKs) Are Critical Mediators of Osteoblast Activity In Vivo. J Bone Miner Res. 2017 Sep;32(9):1811-1815. doi: 10.1002/jbmr.3184. PMID: 28561373; PMCID: PMC5599178.

• Greenblatt MB, Shin DY, Oh H, Lee KY, Zhai B, Gygi SP, Lotinun S, Baron R, Liu D, Su B, Glimcher LH, Shim JH. MEKK2 mediates an alternative β-catenin pathway that promotes bone formation. Proc Natl Acad Sci U S A. 2016 Mar 1;113(9):E1226-35. doi: 10.1073/pnas.1600813113. Epub 2016 Feb 16. PMID: 26884171; PMCID: PMC4780654.